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We've used titanium dioxide safely for decades. However, recently its safety was called into question. 
 
At CRIS, we've explored the safety of titanium dioxide for nearly half a decade, including conducting double-blind research to test the safety of food-grade titanium dioxide (E171). Our study shows that when exposed to food-grade titanium dioxide in normal conditions, research animals did not experience adverse health outcomes.
 
It's important to emphasize that in a National Institutes of Health study, experimental animals were exposed to titanium dioxide in amounts as high as 5% of their diet for a lifetime and showed no evidence of adverse effects. 
 
A handful of studies greatly influenced the decisions made by the European Food Safety Authority (EFSA). Unfortunately, these studies did not consider that titanium dioxide exposure comes from food, not drinking water. Additionally, CRIS researchers could not reproduce the adverse outcomes identified by the studies through typical food ingestion. Regardless, the EFSA banned E171 as a food ingredient and for use in other capacities in the summer of 2022.
 
In 2022, the United States, United Kingdom, and Canada maintained that the scientific evidence supports that titanium dioxide (E171) is safe for humans to use and consume.

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On the other hand, the U.S. Food and Drug Administration (FDA) in their Final Administrative Order on Sunscreen Drug Products posted in September 2021 still accepts titanium dioxide up to 25% in the list of Generally Recognized As Safe and Effective (GRASE) in the main document, without further clarification on what kind or size of particles [9]. However, on page 24 (Sunscreen containing nanomaterials) FDA clearly “distinguish nanomaterials from other forms of these ingredients'' (zinc oxide and titanium dioxide) and ask for comments on “any particular nanomaterials that you believe should not be permitted for use in OTC sunscreen products”. To the best of our knowledge, this Agency did not ban the use of nanoparticulate titanium dioxide in any form, even though it is mentioned on page 34 that the anatase form is the more photoactive one, due to the lack of evidence with real sunscreens OTC (over the counter) in vivo. Moreover, other regulations in Latin America (MERCOSUR agreement, 2006) do not state clearly their position on the use of nanoparticulate TiO2NPs [10].

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Overall, the use of titanium dioxide by manufacturers is essential for various industries, providing valuable properties and benefits for a wide range of products. As technology advances and new applications are discovered, the demand for titanium dioxide is expected to continue to grow. Manufacturers will need to adapt and innovate to meet the evolving needs of their customers while ensuring the safety and sustainability of their products.


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Suppliers of lithopone ZnS-BaSO4 are committed to maintaining strict quality control measures throughout the manufacturing process. They ensure that the raw materials, zinc oxide and sulfur, as well as barium sulfate, are sourced from reliable suppliers to guarantee consistency in the final product. Advanced production techniques, such as precipitation and calcination, are employed to refine the pigment, ensuring its purity and uniform particle size distribution.

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{随机栏目} 2025-08-14 04:40 1976
  • In conclusion, Lomon Titanium Dioxide R-996 rutile pigment is more than just a white powder; it is a high-performance ingredient that transforms products with its superior whiteness, durability, and eco-conscious production. As a testament to Lomon's dedication to innovation and excellence, R-996 continues to set new benchmarks in the pigment industry, solidifying its position as a premier choice for manufacturers worldwide. Whether it's enhancing the aesthetics of coatings or adding strength to plastic products, R-996 rutile titanium dioxide from Lomon stands as a shining example of quality and functionality.

    {随机栏目} 2025-08-14 04:36 1262